Vaccines are considered safe in this population group, although the immune response may be lower than usual in the general population.
Immunocompromised people (including people living with HIV, regardless of the CD4+ count) or people receiving immunosuppressive therapy (including corticosteroids that can be used in the COVID-19 treatment) may have an increased risk of suffering severe COVID-19. Although there are no definitive data on safety and effectiveness of vaccines in these people, they may receive the vaccine if they are part of a group recommended for vaccination and they do not have contraindications for vaccination. On the other hand, until more information is available, no discontinuation of immunosuppressive therapy is recommended.
In the case of vaccines that do not contain live viruses, such as mRNA vaccines and vector vaccines, convalescent plasma or monoclonal antibodies used for COVID-19 treatment would not contraindicate vaccine reception, although to prevent interference with the immune response to the vaccine, it is advisable to delay vaccination at least 90 days.