02
Vaccine and infection

Does vaccination protect against transmission? If not, how will we ever get back to normal life?

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20/6/2021

Although we can assume clinical protection for any subject who has been correctly vaccinated, and a certain degree of reduction in the risk of transmission in the vaccinated subject could be expected with the existing knowledge, the rest of the infection control measures should currently be followed, regardless of vaccination status until we have clear evidence of the impact of vaccines against transmission.

Interestingly, we are starting to receive some real-world data pointing out that these vaccines may impact also transmission and not only protect against clinical disease. For example, data from Israel[1],[2],showing that the viral load is reduced 4-fold for infections occurring 12-28days after the first dose of Comirnaty® BNT162b2 mRNA vaccine, hint to lower infectiousness, further contributing to vaccine impact on virus spread.

[1] E. Petter et al. Initial real world evidence for lower viral load of individuals who have been vaccinated by BNT162b2. medRxiv.org. doi: 10.1101/2021.02.08.21251329.

[2] M. Levine-Tiefenbrun et al. Decreased SARS-CoV-2 viral load following vaccination. medRxiv.org. doi: 10.1101/2021.02.06.21251283.

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