In general, persons with an immediate allergic reaction to the first dose should not receive additional doses of the same vaccine. For the purposes of this guidance, an immediate allergic reaction to a vaccine or medication is defined as any hypersensitivity-related signs or symptoms, such as anaphylaxis, urticaria, angioedema, respiratory distress (e.g. wheezing, stridor), that occur within hours of administration. However, subject to individual risk-benefit assessment, specialist services for immunization may allow COVID-19 vaccines to be provided under close medical supervision if it is the only available option for persons at high risk of severe COVID-19.
As a small number of anaphylactic reactions have also been reported in vaccinees without a history of severe allergic reactions, WHO recommends that COVID-19 vaccines should be administered only in settings where anaphylaxis can be treated. Until more data and insights are available with regard to severe allergic reactions to COVID-19 vaccination, all vaccinees should be observed for at least 15 minutes after vaccination.
Immediate or severe reactions after a previous dose are contraindication.
Administer COVID-19 vaccines only where anaphylaxis can be treated.
Observe all vaccinees at least 15 minutes after vaccination.