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Safety

Why have some women experienced changes to their menstrual cycle following COVID-19 vaccination and can this affect fertility?

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5/23/2022

There is no evidence whatsoever that COVID-19 vaccination could affect fertility. There have been some reports on minor and temporary changes to women’s menstrual cycle following vaccination. More research is being conducted to understand whether there is a causal link and potential mechanisms involved, for example whether vaccination causes an immune response that might temporarily influence the menstrual cycle. In any case, with the currently available evidence there is no reason to link COVID-19 vaccination and fertility issues.

References:

  • Alvergne A, et al. COVID-19 vaccination and menstrual cycle changes: A United Kingdom (UK) retrospective case-control study. medRxiv. 2021, 25/nov. DOI: 10.1101/2021.11.23.21266709
  • Edelman A, et al. Association Between Menstrual Cycle Length and Coronavirus Disease 2019 (COVID-19) Vaccination. A U.S. Cohort. Obstet Gynecol. 2022, 5/ene. DOI: 10.1097/AOG.0000000000004695
  • Gavi, 13/ene de 2022. How COVID-19 vaccines affect the menstrual cycle. Emerging evidence suggests that COVID-19 vaccination does impact menstrual cycle length – but the effect is minor and temporary.
  • Khan SM, et al. SARS-CoV-2 infection and subsequent changes in the menstrual cycle among participants in the Arizona CoVHORT study. Am J Obstet Gynecol. 2022;226(2):270-3
  • Lee KMN, et al. Characterizing menstrual bleeding changes occurring after SARS-CoV-2 vaccination. medRxiv. 2021, 12/oct. DOI: 10.1101/2021.10.11.21264863.
  • Li K, et al. Analysis of sex hormones and menstruation in COVID-19 women of child-bearing age. Reprod Biomed Online. 2021;42(1):260-7.
  • Male V. Effect of COVID-19 vaccination on menstrual periods in a retrospectively recruited cohort. medRxiv. 2021, 15/nov. DOI: 10.1101/2021.11.15.21266317.
  • Male V. Menstrual changes after covid-19 vaccination. BMJ. 2021;374:n2211.
  • Male V. Menstruation and covid-19 vaccination. BMJ. 2022;376:o142. NIH, News releases, 25/ene de 2022. COVID-19 vaccines linked to small increase in menstrual cycle length.
  • Sharp GC, et al. The COVID-19 pandemic and the menstrual cycle: research gaps and opportunities. Int J Epidemiol. 2021, 2/dic. DOI: 10.1093/ije/dyab239
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