Some people with chronic liver diseases may have an impaired immune system or may receive immunosuppression treatment. Immunocompromised people are at increased risk of severe COVID-19 illness and death. All WHO emergency use listed vaccines provide significant protection from severe COVID-19 disease and are safe for people who are immunocompromised.
The immune response to COVID-19 vaccination and the gained protection in immunocompromised people may not be as strong as compared with the rest of the population. Therefore, immunocompromised individuals and their close contacts should receive an extended (3-dose) primary vaccination series followed by a first and second booster dose administered at an interval of 3–6 months.
Reported research data do not support the idea that COVID-19 vaccination induces autoimmune hepatitis (AIH).